Scorcese confirmed the two would film “The Irishman” together while speaking at a BAFTA ceremony, Digital Spy reported.
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The movie is based on the novel “I Heard You Pain Houses” about the true-life story of union boss turned mobster Frank “The Irishman” Sheeran.
Filming is scheduled to begin in 2011.
De Niro and Scorsese first worked together on 1973’s “Mean Streets.” They went on to become one of Hollywood’s most successful and prolific director/actor combinations, churning out “Taxi Driver,” “New York, New York,”” Raging Bull,” “The King Of Comedy,” “Goodfellas,” “Cape Fear,” and “Casino” over the next 20 years.