The New York Giants injury woes continue as they lose another key player.  Wide receiver Mario Manningham will not play on Sunday against the Philadelphia Eagles due to a concussion.  Read more after the jump.

@Shay_Marie x @gametimegirl

Manningham did not travel with the team on Saturday to Philadelphia and was downgraded from doubtful to out.

Defensive end Osi Umenyiora, declared out on Friday as he recovers from arthroscopic knee surgery in mid-August, and cornerback Prince Amukamara (foot) also did not make the trip.

Manningham suffered a concussion in the first half against the Rams on Monday night. He was held out of practice all week long and was considered a long shot to play against the Eagles.

Eli Manning will face Philadelphia’s vaunted secondary — featuring Nnamdi Asomugha, Asante Samuel and Dominique Rodgers-Cromartie — without his second- and third-best receivers with Manningham sidelined by the concussion and Domenik Hixon out for the season with a torn anterior cruciate ligament.

The Giants likely will start Victor Cruz at wide receiver opposite Hakeem Nicks with Manningham out. Cruz and Brandon Stokley also could see time in the slot with DevinThomas perhaps seeing more snaps.

The Giants also signed Michael Clayton on Friday to provide depth and help on special teams.

ESPN