A company by the name of Crisp App has an iOS app essentially enables iPod touch and iPhone users to call their Facebook friends (even if they’re logged on via the web) using a VoIP protocol…see details.
@TatWza

There doesn’t appear to be any affiliation actually with facebook . It also allows chatters to shoot over pictures, browse message history, view a friend’s wall, use emoticons, receive instant replies with Apple Push Notifications and setup sound notifications. Naturally, it supports background operation, but there’s a significant amount of lag present while calling. $2.99 for now.

iTunes