Neil Patrick Harris has been tapped to serve as host of Spike TV’s 2010 Video Game Awards.

“Neil is a big gamer and a brilliant host,” Casey Patterson, the event’s executive producer, said in a statement Monday. “Video games are taking over the world and Neil is perfect to lead the ‘VGAs’ in celebrating the best of the year and the future of gaming.”

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Among the star-studded list of presenters, attendees and nominees for Saturday’s event are Annalynne McCord, Chris Hemsworth, Dane Cook, Olivia Munn, Denise Richards, Guillermo Del Toro, Nathan Fillion, Nick Swardson, Tony Hawk and cast members from the hit series “It’s Always Sunny in Philadelphia” Danny Devito, Kaitlin Olson and Rob McElhenney.

Additional guest appearances will be announced shortly, Spike TV said.

Rock band and “Gran Turismo 5” soundtrack contributors My Chemical Romance are to perform at this year’s event, which is to air live on the cable network.